کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222648 1494675 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison study of porous, fused-core, and monolithic silica-based C18 HPLC columns for Celestoderm-V Ointment® analysis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Comparison study of porous, fused-core, and monolithic silica-based C18 HPLC columns for Celestoderm-V Ointment® analysis
چکیده انگلیسی

In this paper, three C18 columns with different substrates (i.e., porous ACE-3 C18, 3 μm, fused-core Halo C18, 2.7 μm, and monolithic Chromolith C18) were compared for the analysis of a pharmaceutical product, Celestoderm-V Ointment®, that contains one active pharmaceutical ingredient, betamethasone-17-valerate and one critical pair of low level impurities, betamethasone-E-enolaldehyde and betamethasone-Z-enolaldehyde. Key column performance for the analysis of pharmaceutical products including selectivity, efficiency, separation impedance, resolution factor, sample loading capacity, linearity and lifetime from the three columns were determined. The potential applications of these three C18 columns for different methods for Celestoderm-V Ointment® analysis are also recommended.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 50, Issue 5, 5 December 2009, Pages 815–822
نویسندگان
, , , , ,