کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223105 | 967881 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of a degradation product in stressed tablets of olmesartan medoxomil by the complementary use of HPLC hyphenated techniques
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
An unknown degradation product (DP-1) increased in olmesartan medoxomil (OLM) tablets stored at 40 °C/75% r.h., reaching 0.72% after 6 months. The molecular weight and fragment information obtained by LC–MS suggested that DP-1 was a dehydrated dimer of olmesartan (OL) and the presence of ester carbonyl group was indicated by solvent-elimination LC–IR analysis. LC–1H NMR confirmed the structure of DP-1 as an esterified dimer of OL. Rapid and accurate identification of the degradation product was achieved by the complementary use of HPLC hyphenated techniques without complicated isolation or purification processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 47, Issue 3, 15 July 2008, Pages 553–559
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 47, Issue 3, 15 July 2008, Pages 553–559
نویسندگان
Tomonori Murakami, Hidetoshi Konno, Naoto Fukutsu, Michinobu Onodera, Takao Kawasaki, Fumiyo Kusu,