کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223260 | 967886 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isolation and characterization of a new human urinary metabolite of diclofenac applying LC–NMR–MS and high-resolution mass analyses
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The nonsteroidal anti-inflammatory drug diclofenac is widely used. Diclofenac is extensively metabolized to several hydroxylated derivatives and their conjugates. The lactam-dehydrate of 4′-hydroxy diclofenac (4′-OHDD) has now been detected as a new urinary metabolite of diclofenac. Isolation was successfully performed using preparative HPLC in three different steps using water, methanol, and acetonitrile, respectively. The structural characterization of 4′-OHDD was achieved by LC–NMR–MS. In addition, specific mass fragmentation pattern could be obtained using LC–high-resolution MS with both positive and negative electrospray ionization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 47, Issue 2, 9 June 2008, Pages 371–376
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 47, Issue 2, 9 June 2008, Pages 371–376
نویسندگان
Dele Stülten, Marc Lamshöft, Sebastian Zühlke, Michael Spiteller,