کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223476 967892 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of the pattern of acetylation of low-molecular-weight chitosan used in biomedical applications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of the pattern of acetylation of low-molecular-weight chitosan used in biomedical applications
چکیده انگلیسی

The microstructure of chitosan, a linear copolymer of glucosamine and N-acetylglucosamine units widely used in biomedical applications, is closely dependent on the conditions of its preparation. Knowledge of the structural differences between chitosan preparations is very important in determining the properties of chitosan and essential for structure-activity analysis where biological systems are concerned. Determination of the pattern of acetylation of chitosan samples (PA parameter) by 13C NMR spectroscopy hitherto required depolymerization of the native chitosans. The present study has demonstrated that this step is not necessary for determining PA of low-molecular-weight chitosan samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 50, Issue 4, 1 November 2009, Pages 587–590
نویسندگان
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