کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223478 | 967892 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Photostability of pitavastatin—A novel HMG-CoA reductase inhibitor Photostability of pitavastatin—A novel HMG-CoA reductase inhibitor](/preview/png/1223478.png)
The photostability of pitavastatin, an HMG-CoA reductase inhibitor used in the treatment of hypercholesterolemia, was investigated. The sample solution was exposed to UV-A radiation and the photodegradation process was monitored by means of spectrophotometric method and HPLC–DAD. Pitavastatin was shown to be photolabile and its photodegradation reaction followed the first-order kinetics with the rate constant k = 3.54 × 10−4 ± 9.43 × 10−6 s−1.The chromatograms revealed the presence of four major photoproducts (PP-1–PP-4). The separated and isolated photolytic products were identified using a mass spectrometer coupled with a time of flight (TOF) analyzer. The main reaction observed during exposure to radiation of pitavastatin was photocyclisation leading to formation of four-ring photoproducts.
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 50, Issue 4, 1 November 2009, Pages 597–601