کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223480 | 967892 | 2009 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids](/preview/png/1223480.png)
Reversed-phase high-performance liquid chromatography (RP-HPLC) is more and more adopted as a fruitful tool for the estimation of several physico-chemical properties of diverse classes of organic compounds. In this frame, derived chromatographic indices have been proposed as effective parameters to measure the lipophilicity (log P or log D) of compounds. Instead, a limited attention has been directed towards the chromatographic evaluation of the Critical Micellar Concentration (CMC), one of the most important parameters employed to study the bile acid physico-chemical profile. We have recently reported on the effectiveness of the derived chromatographic index φ0 for the study of the self-aggregation process of bile acids. Here we show that this index is independent upon the adopted chromatographic environment so as to be instrumental for the evaluation of the hydrophobic/hydrophilic balance of bile acids. Molecular modelling studies have also been undertaken with the aim of rationalizing the experimental findings.
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 50, Issue 4, 1 November 2009, Pages 613–621