کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1223548 | 967894 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Racemization of 6-methoxydihydrosanguinarine in methanol investigated by enantioselective dynamic HPLC
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
A biologically active benzophenanthridine alkaloid, 6-methoxydihydrosanguinarine (MS), was isolated from Hylomecon plants. Although enantiomers of MS can be separated by chiral HPLC, its isomers rapidly form a racemic mixture in methanol. The rate constants for the racemization of MS enantiomers were 9.20 × 10−4 s−1 and 9.95 × 10−4 s−1 for (+)-MS and (−)-MS, respectively, as determined by dynamic HPLC and chiral chromatography. This unusually rapid racemization may originate from the formation of a stable iminium ion intermediate, sanguinarine. Therefore, the variety of biological activities exhibited by MS may be attributable to a combination of (+)-MS, (−)-MS, and sanguinarine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 51, Issue 1, 5 January 2010, Pages 103–106
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 51, Issue 1, 5 January 2010, Pages 103–106
نویسندگان
Enqi Wu, Sang-Hun Jung, Jianbo Chen, Young Ho Kim, Kyung Lae Park, Wonjae Lee, Jong Seong Kang,