کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223672 967898 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent applications of liquid chromatography–mass spectrometry in natural products bioanalysis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Recent applications of liquid chromatography–mass spectrometry in natural products bioanalysis
چکیده انگلیسی

Natural flavonoids, alkaloids, saponins and sesquiterpenoids have been extensively investigated because of their biological and physiological significances, as well as their promising clinical uses. It is necessary to monitor them or their metabolites in biological fluids for both pre-clinical studies and routine clinical uses. The successful hyphenation of LC and MS, which was thought as “the bird wants to marry with fish”, has been conducted widely in biological samples analysis. This present paper reviewed the feasibility of LC–MS techniques in the identification and quantification of natural products (flavonoids, alkaloids, saponins and sesquiterpenoids) in biological fluids, dealing with sample preparation, LC techniques, suitability of different MS techniques. Perspective of LC–MS was also discussed to show the potential of this technology. The citations cover the period 2002–2006. We conclude that LC–MS is an extremely powerful tool for the analysis of natural products in biological samples.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 2, 28 June 2007, Pages 368–378
نویسندگان
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