کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223879 967903 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection limit of measurement of pharmaceuticals labeled with short-lived isotopes in HPLC with flow-through γ-counter
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Detection limit of measurement of pharmaceuticals labeled with short-lived isotopes in HPLC with flow-through γ-counter
چکیده انگلیسی

This paper proposes a method for estimating the detection limit, which is defined as 3.3 times the standard deviation (S.D.) of blank measurements under the situations where the repetition of measurement is difficult or impossible because of a short half-life of radioactivity. The FUMI theory, which can estimate an S.D. value without repetition in various instrumental analyses, is adopted and proved here to be available in a radio-HPLC system as well. 99mTc-ECD (T1/2 = 360.6 min) that is a lipophilic compound for the diagnosis of regional brain perfusion is taken as an example.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 46, Issue 1, 7 January 2008, Pages 177–180
نویسندگان
, , , , ,