کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1223964 967905 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
چکیده انگلیسی

Rapid chromatographic procedures for analytical quality control of pharmaceutical preparations containing antihistamine drugs, alone or together with other kind of compounds are proposed. The method uses C18 stationary phases and micellar mobile phases of cetyltrimethylammonium bromide (CTAB) with either 1-propanol or 1-butanol as organic modifier. The proposed procedures allow the determination of the antihistamines: brompheniramine, chlorcyclizine, chlorpheniramine, diphenhydramine, doxylamine, flunarizine, hydroxyzine, promethazine, terfenadine, tripelennamine and triprolidine, in addition to caffeine, dextromethorphan, guaifenesin, paracetamol and pyridoxine in different pharmaceutical presentations (tablets, capsules, suppositories, syrups and ointments). The methods require minimum handling sample and are rapid (between 3 and 12 min at 1 mL min−1 flow rate) and reproducible (R.S.D. values < 5%). Limits of detection are lower than 1 μg mL−1 and the recoveries of the analytes in the pharmaceutical preparations are in the range 100 ± 10%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 40, Issue 2, 13 February 2006, Pages 312–321
نویسندگان
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