کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224478 | 967923 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Automated determination of flutamide by a validated flow-injection method: Application to dissolution studies of pharmaceutical tablets
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The first flow-injection (FI) method for the determination of flutamide - a potent antiandrogen used for the treatment of prostate cancer - is reported. The method is based on the direct measurement of the absorbance of the analyte at 310Â nm under flow conditions. Parameters affecting the determination such as detection wavelength, sample injection volume and flow rate were studied and optimized. The assay was validated (linearity, limits of detection and quantitation, accuracy, repeatability, reproducibility and selectivity) for the dissolution studies of flutamide-containing tablets during stability testing. The results were in good agreement with high performance liquid chromatography (HPLC) used as a reference method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 43, Issue 5, 11 April 2007, Pages 1820-1824
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 43, Issue 5, 11 April 2007, Pages 1820-1824
نویسندگان
Paraskevas D. Tzanavaras, Demetrius G. Themelis,