کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224589 | 967926 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimization of entrapment of metronidazole in amphiphilic β-cyclodextrin nanospheres
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Optimization of entrapment of metronidazole in amphiphilic β-cyclodextrin nanospheres Optimization of entrapment of metronidazole in amphiphilic β-cyclodextrin nanospheres](/preview/png/1224589.png)
چکیده انگلیسی
Several aspects of the manufacture of nanospheres containing metronidazole were studied. Nanospheres made of amphiphilic β-cyclodextrin containing metronidazole were prepared by adding an acetone solution of amphiphilic cyclodextrin to an aqueous solution of metronidazole with or without Pluronic PE/F68® as the surfactant. An optimized formulation with high encapsulation efficiencies and with an appropriate particle size for intravenous administration, was developed.The entrapment of metronidazole was strongly dependent of the method of preparation and drug concentrations. These nanospheres prepared by nanocrystallization are promising carriers for metronidazole in the treatment of hepatic abscess.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 3, 7 June 2006, Pages 1017–1021
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 3, 7 June 2006, Pages 1017–1021
نویسندگان
Malika Lahiani-Skiba, Frederic Bounoure, Sozan Shawky-Tous, P. Arnaud, Mohamed Skiba,