کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224611 | 967927 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection Simultaneous determination of nitrendipine and one of its metabolites in plasma samples by gas chromatography with electron-capture detection](/preview/png/1224611.png)
چکیده انگلیسی
A sensitive method for GC-ECD simultaneous determination of nitrendipine and its pyridine metabolite M1 in human plasma is described. Felodipine was used as the internal standard. The plasma samples were extracted with toluene. One microlitre of the extract was injected onto the capillary column (polymethylsiloxane) and measured with electron-capture detector. The developed method showed to be linear over the range 0.25-70 for nitrendipine and 0.3-61Â ng/ml for its metabolite M1 with an inter-day and intra-day precision in terms of R.S.D. lower than 8% except the concentrations near lowest limit of quantification (LLOQ) (<11% R.S.D.). The LLOQ for nitrendipine was 0.25 and 0.3Â ng/ml for its metabolite, respectively. The analytical recovery was 94% for nitrendipine and 89% for its pyridine metabolite M1. This GC-ECD method was developed for being used in clinical pharmacokinetic studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 3, 27 July 2007, Pages 674-679
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 44, Issue 3, 27 July 2007, Pages 674-679
نویسندگان
J. Pastera, L. MejstÅÃková, J. Zoulová, K. Macek, J. KvÄtina,