کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224660 | 967928 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations Development and validation of reversed phase high performance liquid chromatography method for determination of dexpanthenol in pharmaceutical formulations](/preview/png/1224660.png)
چکیده انگلیسی
This paper describes the validation of an isocratic HPLC method for the assay of dexpanthenol in aerosol and gel. The method employs the Vydac Proteins C4 column with a mobile phase of aqueous solution of trifluoroacetic acid and UV detection at 206 nm. A linear response (r > 0.9999) was observed in the range of 13.0–130 μg mL−1. The method shows good recoveries and intra and inter-day relative standard deviations were less than 1.0%. Validation parameters as specificity, accuracy and robustness were also determined. The method can be used for dexpanthenol assay of panthenol aerosol and gel with dexpanthenol as the method separates dexpanthenol from aerosol or gel excipients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 43, Issue 3, 19 February 2007, Pages 983–988
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 43, Issue 3, 19 February 2007, Pages 983–988
نویسندگان
A.U. Kulikov, A.A. Zinchenko,