کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1224968 | 967940 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
HPCE methodology was modified to be used in kinetic experiments on photooxidation reactions of papaverine hydrochloride 1 and its oxidation products (papaverinol 2 and papaveraldine hydrochloride 3) chloroform solutions exposed to UV254 light in aerobic conditions. On photooxygenation of the above compounds is formed the final degradation product, a brown compound X 4, 2,3,9,10-tetramethoxy-12-oxo-12H-indolo[2,1-a]isoquinolinylim chloride. The rate of 4 formation from the above compounds can be given as 2Â >Â 3Â >Â 1Â >Â 1 HCl. The photooxidation reactions of 1 and 2 proceed with pseudo first-order kinetics and that reaction for 3 follows zero-order kinetics. The most labile compound is 2 whose half-life time is 2.4 times shorter than that one of 1 HCL. The most stable product is 3 whose half-life time is 31-fold longer than of 2. The specific quantum yields are equal 0.28, 0.30 and 0.10 for 1 HCl, 2 and 3, respectively which confirm the above stability pattern of the compounds concerned.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 4, 16 June 2006, Pages 1391-1395
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 4, 16 June 2006, Pages 1391-1395
نویسندگان
Karolina Piotrowska, Tadeusz WÅadysÅaw Hermann, WÅodzimierz Augustyniak,