کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1224974 967940 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of related impurities in megestrol acetate
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Characterization of related impurities in megestrol acetate
چکیده انگلیسی
Three new compounds, 17α-acetoxy-2,6-dimethylpregna-1,4,6-triene-3,20-dione (1), 17α-acetoxy-2α,6-dimethylpregna-4,6-diene-3,20-dione (2), 17α-acetoxy-6α-methoxylmethylpregna-4-ene-3,20-dione (3), together with five known ones, 17α-acetoxy-6β-hydroxyl-6α-methylpregna-4-ene-3,20-dione (4), 17α-acetoxy-6α-hydroxyl-6β-methylpregna-4-ene-3,20-dione (5), 17α-acetoxy-pregna-4-ene-3,6,20-trione (6), 17α-acetoxy-pregna-4-ene-3,20-dione (7) and 17α-acetoxy-6-methylene-pregna-4-ene-3,20-dione (8), were isolated and identified from the residual mother liquor of megestrol acetate. Their structures were established by spectroscopic methods. These compounds seem to be minor impurities in production of the drug megestrol acetate.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 4, 16 June 2006, Pages 1418-1422
نویسندگان
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