کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1225076 | 967944 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular lipophilicity determination of a huperzine series by HPLC: Comparison of C18 and IAM stationary phases
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Two hydrophobic parameters (log kwâC18 and log kwâIAM, respectively) of a huperzine A series were extrapolated by high performance liquid chromatography (HPLC) using both C18 and immobilised artificial membrane (IAM) columns. A mathematical correlation between C18 and IAM hydrophobic parameters was completed, suggesting a similar behaviour on both columns. This behaviour was principally led by hydrophobic forces. The theoretical lipophilicity (log P) of each compound was computed using Pallas® software and compared to experimental values, showing a similar lipophilic behaviour. Finally, the huperzine log kwâIAM and log kwâC18 values were correlated with the relative bound percentage of huperzine in human serum albumin, confirming that hydrophobic forces are predominant in the huperzine-HSA binding mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 1, 11 April 2006, Pages 228-232
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 1, 11 April 2006, Pages 228-232
نویسندگان
François Darrouzain, Philippe Dallet, Jean-Pierre Dubost, Lhassane Ismaili, Fabienne Pehourcq, Bernard Bannwarth, Myriam Matoga, Yves C. Guillaume,