کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1225076 967944 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular lipophilicity determination of a huperzine series by HPLC: Comparison of C18 and IAM stationary phases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Molecular lipophilicity determination of a huperzine series by HPLC: Comparison of C18 and IAM stationary phases
چکیده انگلیسی
Two hydrophobic parameters (log kw−C18 and log kw−IAM, respectively) of a huperzine A series were extrapolated by high performance liquid chromatography (HPLC) using both C18 and immobilised artificial membrane (IAM) columns. A mathematical correlation between C18 and IAM hydrophobic parameters was completed, suggesting a similar behaviour on both columns. This behaviour was principally led by hydrophobic forces. The theoretical lipophilicity (log P) of each compound was computed using Pallas® software and compared to experimental values, showing a similar lipophilic behaviour. Finally, the huperzine log kw−IAM and log kw−C18 values were correlated with the relative bound percentage of huperzine in human serum albumin, confirming that hydrophobic forces are predominant in the huperzine-HSA binding mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 41, Issue 1, 11 April 2006, Pages 228-232
نویسندگان
, , , , , , , ,