کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1225536 | 968230 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses. We describe here the immunoprotective activity in an in vivo animal model of a serotype-2 cell wall protein, designated Sat, which was identified by a previously validated proteomics approach consisting of the protease digestion of live bacteria and the selective recovery of exposed domains, followed by LC/MS/MS analysis. Increased survival rate (80%) and decreased bacterial burden were observed in mice immunized with a recombinant Sat fragment, suggesting that this protein is a potential vaccine candidate against serotype-2 infection.
Figure optionsDownload high-quality image (42 K)Download as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 73, Issue 12, 10 November 2010, Pages 2365–2369
Journal: Journal of Proteomics - Volume 73, Issue 12, 10 November 2010, Pages 2365–2369
نویسندگان
Francesca Mandanici, Lidia Gómez-Gascón, Manuela Garibaldi, Alfonso Olaya-Abril, Inmaculada Luque, Carmen Tarradas, Giuseppe Mancuso, Salvatore Papasergi, J. Antonio Bárcena, Giuseppe Teti, Concetta Beninati, Manuel J. Rodríguez-Ortega,