کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1225627 968239 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease
چکیده انگلیسی

Alzheimer's disease (AD) is the most common cause of dementia of late life. To enhance our understanding of AD proteome, the serum proteins were analyzed using two-dimensional gel electrophoresis (2DE) combined with nano-high performance liquid chromatography electrospray ionization tandem mass spectrometry (nano-HPLC-ESI-MS/MS) followed by peptide fragmentation patterning. In this study, six protein spots with differential expression were identified. Five up-regulated proteins were identified as actin, apolipoprotein A-IV (Apo A-IV), inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), alpha-1-antitrypsin (AAT), and antithrombin-III (AT-III); one protein, activity-dependent neuroprotector homeobox protein (ADNP) was down-regulated in AD patients. These proteins with differential expression in the serum may serve as potential indicators of AD. Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD.

Figure optionsDownload high-quality image (35 K)Download as PowerPoint slideHighlights
► We used proteomic approaches in an attempt to identify the serum biomarkers for AD.
► Six proteins with differential expression were identified in AD serum samples.
► ADNP may play an important role in slowing the progression of AD clinical symptoms.
► The identified proteins are valuable for screening biomarkers for further AD study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 75, Issue 12, 27 June 2012, Pages 3617–3629
نویسندگان
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