کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1225771 968251 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of the human ventricular cerebrospinal fluid proteome obtained from hydrocephalic patients
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Characterization of the human ventricular cerebrospinal fluid proteome obtained from hydrocephalic patients
چکیده انگلیسی

The continuing expansion of proteomic technology has been fueled by the potential for discovering novel biomarkers that may be used for the early detection of disease. It has been proposed that human cerebrospinal fluid (CSF), which surrounds and protects the brain and spinal cord from traumatic injury, may be a valuable target for the diagnosis of a variety of conditions such as Alzheimer's disease, traumatic brain injury, amyotrophic lateral sclerosis and Parkinson's disease. The immense complexity of biofluids, however, still requires that considerable development be made in the analytical techniques used so that comprehensive coverage of the proteins present in such samples is achieved. Using a simple separation strategy the protein complement of human ventricular cerebrospinal fluid obtained from patients with hydrocephalus was evaluated. The study resulted in the identification of over 1500 unique proteins that were found within all nine CSF samples that were analyzed. Comparison with the HUPO serum proteome database demonstrated that human ventricular CSF contains a large array of proteins that may be unique to CSF. This analysis greatly increases our knowledge of the protein content of this clinically important biofluid.

Identification of the ventricular cerebrospinal fluid proteome obtained from nine hydrocephalus patients.Figure optionsDownload high-quality image (197 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Proteomics - Volume 73, Issue 6, 18 April 2010, Pages 1156–1162
نویسندگان
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