کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1229683 1495234 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flow-injection chemiluminescence determination of cloxacillin in water samples and pharmaceutical preparation by using CuO nanosheets-enhanced luminol–hydrogen peroxide system
ترجمه فارسی عنوان
تعیین چای مایلومیناسیون جریان تزریقی کلکساسیلین در نمونه های آبی و آماده سازی داروی با استفاده از سیستم لومینولا پراکسید هیدروژن لومینولا
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Well-crystalline CuO NSs by an ultrasonic assisted precipitation method.
• CuO NSs as an excellent catalyst for luminol–H2O2 CL system.
• Determination of cloxacillin using luminol–H2O2–CuO NSs flow injection CL system.
• Investigation of enhancement mechanism of cloxacillin on the CL mechanism.

In this paper, a rapid and sensitive flow-injection chemiluminescence (flow-CL) system was developed for the determination of cloxacillin sodium in environmental water samples and pharmaceutical preparations. The method was based on the enhancement effect of cloxacillin sodium on the CL reaction of luminal–H2O2–CuO nanosheets (NSs) in alkaline medium. The CuO nanosheets were synthesized using a green sonochemical method. The physical properties of the synthesized CuO nanosheets were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses. The influences of various experimental factors such as H2O2, NaOH, luminol and CuO nanosheets concentrations were investigated. Under the optimum conditions, the enhanced CL intensity was linearly related to the concentration of cloxacillin sodium in the range of the 0.05–30.00 mg L−1 with a correlation coefficient of 0.995. The corresponding detection limit (3σ) was calculated to be 0.026 mg L−1. The relative standard deviation (RSD) of the developed method was 2.21% with 11 repeated measurements of 4.00 mg L−1 cloxacillin sodium. Also, a total analysis time per sample was 30 s which confirmed the rapidity of the proposed method. The analytical applicability of the proposed CL system was assessed by determining cloxacillin sodium in spiked environmental water samples and pharmaceutical preparation. Furthermore, the possible mechanism of CL reaction was discussed.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 134, 5 January 2015, Pages 210–217
نویسندگان
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