Synthesis, spectral characterization and antimicrobial studies of novel s-triazine derivatives

A series of fifteen novel triazinyl derivatives, with various natural nucleobases by mono, di and tri substitution in cyanuric chloride at the 2,4- and/or 6-positions was synthesized. Target molecules were synthesized by stoichiometric addition of various nucleophiles to cyanuric chloride in the presence of suitable base. The structural characterizations of all the compounds were made by spectral and analytical techniques, IR, 1H NMR, 13C NMR, and 2D NMR (HSQC, HMBC), mass spectral and elemental analysis. All the synthesized compounds were screened for in vitro antimicrobial activity against a panel of selected bacterial and fungal strains using Streptomycin and Amphotericin B as standards. The minimum inhibition concentration (MIC) results revealed that most of the purine (1a–2a, 1b–2b, and 1c–2c) compounds exhibit excellent activity against selected bacterial and fungal strains.

Figure optionsDownload as PowerPoint slideHighlights
► Series of novel hybrids s-triazine derivatives were synthesized and characterized.
► Formation of the novel hybrids were confirmed by 1D, 2D NMR and HR-MS spectroscopy.
► Excellent and moderate antimicrobial activities were observed.