Study of the voltammetric behavior of jatrorrhizine and its sensitive determination at electrochemical pretreatment glassy carbon electrode

• Electrochemical properties of jatrorrhizine were investigated for the first time.
• The resulting sensor showed a significant voltammetric response to jatrorrhizine.
• This electroanalytical method is used in clinical study and in the fields of pharmaceutical analysis.

A simple, inexpensive and highly sensitive electrochemical method for the determination of jatrorrhizine was developed using an electrochemically pretreated glassy carbon electrode (EPGCE). The electrochemical behavior of jatrorrhizine was systematically investigated in detail and some kinetic parameters were calculated for the first time. A reasonable reaction mechanism of jatrorrhizine on the EPGCE was also discussed and proposed, which could be a reference for the pharmacological action of jatrorrhizine in clinical study. And the first electroanalytical method of jatrorrhizine was established with a wide linear range from 7.0×10−8 to 2.0×10−5 mol L−1 and a low detection limit of 5.0×10−8 mol L−1. The proposed method was successfully applied in determination of jatrorrhizine in pharmaceutical sample, Tinospora capillipes Gagnep (a traditional Chinese medicine), with satisfactory results.

A simple sensor for high-sensitive determination of jatrorrhizine based on electrochemical pretreatment glassy carbon electrode, which was prepared by cyclic voltammetry (EPGCE). Compared with bare GCE, there is a dramatic increase of the oxidation peak currents. Then the electrochemical behavior of jatrorrhizine was carefully and systematically investigated and some kinetic parameters were calculated for the first time. The first electroanalytical method of jatrorrhizine was also established and applied in pharmaceutical sample analysis.Figure optionsDownload as PowerPoint slide