کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1245336 | 1495854 | 2006 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prostatic Zn determination for prostate cancer diagnosis Prostatic Zn determination for prostate cancer diagnosis](/preview/png/1245336.png)
We present our studies of prostatic Zn concentration measurements, carried out in the light of a novel prostate cancer (CAP) diagnosis method proposed by us. The method is based on in vivo prostatic Zn mapping by XRF trans-rectal probe.We report on the extensive clinical studies, intended to assess the validity of the novel proposed diagnostic method. Zn content was measured in vitro in needle-biopsy samples from several hundreds of patients, and was correlated with histological findings and other patient parameters. For this purpose, a technique of absolute Zn content determination in ∼1 mm3 fresh tissue samples by XRF was developed. The experimental details and the main clinical-evaluation results are presented.We further outline the suggested design of the XRF trans-rectal probe for an efficient in vivo detection and mapping of the Zn fluorescence radiation from the prostate through the rectal wall. Laboratory phantom studies, a preliminary design concept and its expected performance are also reported.
Journal: Talanta - Volume 70, Issue 5, 15 December 2006, Pages 914–921