Anodic voltammetric behavior of resveratrol and its electroanalytical determination in pharmaceutical dosage form and urine

The anodic voltammetric behavior of resveratrol was studied using cyclic and square wave voltammetric techniques. The oxidation of resveratrol is irreversible and exhibits an adsorption controlled process which is of pH dependence. The oxidation mechanism was proposed in this work. The dependence of the current on pH, the concentration and nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of resveratrol. It was found that the optimum buffer for the determination of resveratrol is 1.0 × 10−3 M KCl + 0.1 M HNO3 solution with the pH of 1.0. In the range of 5.00 × 10−9 to 1.65 × 10−7 M, the current measured by square wave voltammetry presents a good linear property as a function of the concentration of resveratrol. In addition, the reproducibility, precision and accuracy of the method were checked as well. The method was applied for the determination of resveratrol in Chinese patent medicine and diluted urine.