کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1246722 969768 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smart electrochemical sensor for some neurotransmitters using imprinted sol–gel films
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Smart electrochemical sensor for some neurotransmitters using imprinted sol–gel films
چکیده انگلیسی

A hybrid sol–gel material formed by acid hydrolysis of a mixture of tetraethylorthosilicate (TEOS) and phenyltriethylorthosilicate (PTEOS) as functional monomers was imprinted by tyramine and dopamine as template molecules for the purpose of molecular recognition. Imprinted materials were spin coated as thin films on the surface of glassy carbon electrodes and then were characterized using cyclic voltammetry (CV). After extraction of the encapsulated molecules, imprinted films were tested in solutions of their templates and other molecules. Rebinding experiments were followed by electrochemical characterization using square wave voltammetry (SWV). Imprinted films showed higher affinities toward their template molecules compared to other structurally similar molecules especially for tyramine imprinted film. With the exception of tyramine and norepinephrine, the interference level did not exceed 5% for all compounds studied for dopamine-imprinted films. Tyramine-imprinted films however showed high affinity to tyramine with dopamine 40% interference. Some factors related to the rebinding ability process like pH of solution, concentration of template were studied. The sensing surface lifetime extended to 2 weeks with decay in response signal that ranged from 22%, 40% to 60% for dopamine, tyramine and norepinephrine, respectively. The standard deviation from the mean of measurements for the repeated experiments is 7.4%. Electrochemical impedance spectroscopy (EIS) measurements confirmed the results obtained by electrochemical measurements. Morphological characteristics of the imprinted thin films and their thickness were investigated using scanning electron microscope (SEM).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Talanta - Volume 80, Issue 2, 15 December 2009, Pages 511–518
نویسندگان
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