Sensitive detection of trifluoperazine using a poly-ABSA/SWNTs film-modified glassy carbon electrode

A poly-ABSA/SWNTs composite-modified electrode was fabricated by electropolymerizing aminobenzene sulphonic acid (ABSA) on the surface of glassy carbon electrode (GCE) modified with single-wall carbon nanotubes (SWNTs). SWNTs provide a 3D porous and conductive network for the polymer immobilization. The nanocomposite film was characterized by scanning electron microscope (SEM) and electrochemical impedance spectroscopy (EIS). The results indicated that this composite-modified electrode had strong electrocatalytic activity toward the oxidation of trifluoperazine (TFP). TFP could effectively accumulate on the modified electrode and generate a sensitive anodic peak at 0.72 V (versus SCE) in pH 6.1 phosphate buffer solution. Under the selected conditions, the anodic peak current of TFP was linear with its concentration within the range from 1.0 × 10−7 to 1.0 × 10−5 mol L−1 and 1.0 × 10−5 to 1.0 × 10−4 mol L−1, and the detection limit was 1.0 × 10−9 mol L−1 (S/N = 3). This method was successfully applied to the detection of trifluoperazine in drug samples and the recovery was satisfactory. In comparison with the SWNTs/GCE or poly-ABSA/GCE prepared in the similar way, this composite-modified electrode exhibited better catalytic activity.