کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1247690 1495887 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems
ترجمه فارسی عنوان
نانوذرات مبتنی بر لیپید جامد به عنوان مواد موثر و هدفمند برای انتقال دارو و سیستم های زایمان
کلمات کلیدی
نانوذرات مبتنی بر لیپید، نانوذرات لیپید جامد، حامل های چرب نانوساختار، دارو و تحویل ژن، همکاری
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Solid lipid-based nanocarriers hold great capacity as targeted delivery systems.
• These systems are promising candidate in the development of targeted drug delivery.
• These systems have capacity for combined drug and gene co-delivery.

Most of the active pharmaceutical ingredients are often prone to display low bioavailability, biological degradation and inadvertent intrinsic side effects. To circumvent such obstacles, the expansion of efficient and novel drug carrier system is of increasing importance in terms of their efficient applicability through different administration routes such as dermal, oral, topical, parenteral and pulmonary. To pursue such aims, as an effective strategy, targeted delivery of drugs/genes to specific tissues/cells has widely been investigated. Accordingly, colloidal delivery of nanosystems such as solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, niosomes and transfersomes have materialized great means towards improved targeted delivery of drug/gene cargoes. The potential advantages of solid lipid-based nanocarriers applications over other nanoparticles (NPs) are because of their high biocompatibility, higher drug loading capacity and scalability. In this study, we review the utility of various targeted solid lipid-based nanocarriers and discuss their applications in drug and gene delivery systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: TrAC Trends in Analytical Chemistry - Volume 77, March 2016, Pages 100–108
نویسندگان
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