کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1248449 | 1495911 | 2014 | 14 صفحه PDF | دانلود رایگان |
• The fourth generation coupled platform of mass spectrometry (MS) is described.
• The recent applications of chip-MS in proteomics and cell analysis are reviewed.
• Chip-MS is an emerging platform for biological analysis.
Microchip-mass spectrometry (chip-MS) has been emerging as an excellent analytical tool in the analysis of complex biological samples. The microchip can play an important role, as in cell culture and sample-preparation steps prior to mass spectral identification, which benefit from its ability to handle small sample quantities with the potential for high-throughput parallel analysis. We describe recent progress in chip-MS, including approaches that combined microchip devices with electrospray ionization and matrix-assisted laser desorption/ionization. We then review the main applications of chip-MS in proteomics and cell analysis in the past three years. We also look at the implications for the future of the field.
Journal: TrAC Trends in Analytical Chemistry - Volume 53, January 2014, Pages 84–97