کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1250550 | 970839 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: NIR spectroscopic study of the dissolution process in pharmaceutical tablets NIR spectroscopic study of the dissolution process in pharmaceutical tablets](/preview/png/1250550.png)
In this study, water penetration and the interaction between water and a pharmaceutical excipient in a tablet were investigated using near-infrared (NIR) spectroscopy and perturbation-correlation moving-window two-dimensional correlation spectroscopy (PCMW-2DCS). The penetration rate of water into a tablet was mainly dependent on the porosity of the tablet and was less dependent on the type of excipient. This behavior was well described by the Lucas–Washburn theory. The PCMW-2DCS technique revealed that there are two-staged interaction changes in NIR spectra of the water–powder interactions. The first and second changes corresponded to the water–solid interaction and the dissolution of the solid, respectively. The diffusion-controlled dissolution model by Nernst well explained these results.
Journal: Vibrational Spectroscopy - Volume 57, Issue 2, November 2011, Pages 275–281