کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1251619 1496285 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bilayer membrane interactions with nanofabricated scaffolds
ترجمه فارسی عنوان
تعامل غشاء بیلایر با داربست های نانو ساختار
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
چکیده انگلیسی

Membrane function is facilitated by lateral organization within the lipid bilayer, includingphase-separation of lipids into more ordered domains (lipid rafts) and anchoring of the membrane to a cytoskeleton. These features have proven difficult to reproduce in model membrane systems such as black lipid membranes, unilamellar vesicles and supported bilayers. However, advances in micro/nanofabrication have resulted in more realistic synthetic models of membrane-cytoskeleton interactions that can help uncover the design rules responsible for biological membrane formation and organization. This review will focus on describing micro-/nanostructured scaffolds that can emulate the connections of a cellular membrane to an underlying “cytoskeleton”. Examples include molecular-based scaffolds anchored to a solid substrate through surface chemistry, solid-state supports modified by material deposition, lithography and etching, the creation of micro/nanoporous arrays, integration with microfluidics, and droplet-based bilayers at interfaces.Model systems such as theseare increasing our understanding of structure and organization in cell membranes, and how they result in the emergence of functionality at the nanoscale.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 192, November 2015, Pages 75–86
نویسندگان
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