کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1252029 1496327 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential conformational behaviors of α-mycolic acids in Langmuir monolayers and computer simulations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Differential conformational behaviors of α-mycolic acids in Langmuir monolayers and computer simulations
چکیده انگلیسی

Phase diagrams of Langmuir monolayers of α-mycolic acids (α-MAs) from representative slow growing mycobacteria were intensively analyzed over a range of temperatures, by using so-called type-1 α-MAs having two cis-cyclopropyl groups from Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium-intracellulare   complex (MAC) and type-3 α-MA, having one cis-cyclopropyl and one cis-double bond from Mycobacterium bovis BCG and MAC. Their intrachain groups are either cis-cyclopropyl or cis  -double bond but the methylene chain segment lengths vary greatly. However, their monolayer features were alike: at lower temperatures and surface pressures, the molecules seemed to be in folded conformations, requiring larger mean molecular areas, whereas at higher temperatures and surface pressures, to be in extended conformations, requiring smaller average molecular areas approximately equivalent to cross sectional area of two hydrocarbon chains in a condensed film. In phase diagrams, the region for the folded forms of α-MAs was very limited, in contrast to the previously established behavior of ketomycolates, where complete folding predominated. Easy conversion of folded to extended conformations was indicated by thermodynamic studies of the Langmuir monolayer results and computer simulations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 163, Issue 6, June 2010, Pages 569–579
نویسندگان
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