Membranes and mammalian glycolipid transferring proteins

• We review glycolipid transferring proteins and how their activity is affected by membranes.
• Structural features of the glycolipid transferring proteins are discussed.
• Intracellular targeting and biological properties are briefly reviewed.

Glycolipids are synthesized in and on various organelles throughout the cell. Their trafficking inside the cell is complex and involves both vesicular and protein-mediated machineries. Most important for the bulk lipid transport is the vesicular system, however, lipids moved by transfer proteins are also becoming more characterized. Here we review the latest advances in the glycolipid transfer protein (GLTP) and the phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) field, from a membrane point of view.

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