کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1299095 1498760 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactive iridium and rhodium complexes as therapeutic agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Bioactive iridium and rhodium complexes as therapeutic agents
چکیده انگلیسی

Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded as chemically inert, studies over the past few years have demonstrated that the reactivity and biological activity of iridium and rhodium complexes may be unlocked by a suitable choice of auxiliary ligands. In addition, group 9 metal centers have received increased popularity for the construction of kinetically inert organometallic scaffolds as target-selective protein or enzyme inhibitors. In this review, we summarize the recent strategies that have been utilized for the design and development of bioactive iridium and rhodium complexes.


► Group 9 metal complexes have emerged as alternatives for designing metallo drugs.
► We surveyed the recent development of group 9 metal complexes as therapeutic agents.
► Interesting examples of protein targeting inert group 9 complexes are highlighted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 257, Issues 11–12, June 2013, Pages 1764–1776
نویسندگان
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