Coordination chemistry of vitamin B6 and derivatives: A structural overview

The coordination behaviour of ligands containing the vitamin B6 vitamers [pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM) and their 5′-phosphates] is reviewed in the light of the structural information derived from X-ray studies. The review includes the complexes of the simple vitamers themselves or simple derivatives thereof; those of the Schiff bases resulting from their condensation with each other or with amino acids or other amino derivatives; and the metal compounds formed by hydrazones that contain the PL moiety. Taken together, these ligands exhibit a wide variety of coordination possibilities, the vitamer moiety usually playing a significant role. The biological relevance and therapeutic potential of some of these compounds are also reviewed.

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► Coordination chemistry of vitamin B6 vitamers (PN, PM and PL).
► PLPM Schiff bases as ligands.
► Exploring the coordination behaviour of PLaa derivatives.
► Metal complexes containing non-reduced and reduced ligands derived from PL and mono-, di- and triamines.
► PL hydrazone complexes.