کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1299621 | 974239 | 2016 | 29 صفحه PDF | دانلود رایگان |

• Synthesis and characterization of RAPTA-type compounds.
• Structural features.
• Mechanistic studies and target identification.
• Biological properties in the treatment of tumors.
Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.
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Journal: Coordination Chemistry Reviews - Volume 306, Part 1, 1 January 2016, Pages 86–114