کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1299621 974239 2016 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The development of RAPTA compounds for the treatment of tumors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
The development of RAPTA compounds for the treatment of tumors
چکیده انگلیسی


• Synthesis and characterization of RAPTA-type compounds.
• Structural features.
• Mechanistic studies and target identification.
• Biological properties in the treatment of tumors.

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has been modified to elucidate the key role of each part and to afford targeted derivatives. The various mechanistic studies conducted on RAPTA compounds are described and these are linked to the observed macroscopic biological properties. Ultimately, the review shows that certain RAPTA compounds display quite unique properties that point towards a clinical investigation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 306, Part 1, 1 January 2016, Pages 86–114
نویسندگان
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