کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1301038 1498755 2013 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative aliphatic carbon–carbon bond cleavage reactions
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Oxidative aliphatic carbon–carbon bond cleavage reactions
چکیده انگلیسی


• Metalloenzyme-catalyzed aliphatic carbon–carbon bond cleavage reactions recently identified.
• Substrates vary in terms of their O2 reactivity in the absence of enzyme.
• Reaction pathways depend on the nature of the substrate; metal versus substrate reactivity with O2.
• Regioselectivity of carbon–carbon bond cleavage influenced by nature of metal ion.
• Model systems providing insight into structure/reactivity relationships.

Over the past decade, several metalloenzymes have been characterized which catalyze dioxygenase-type aliphatic carbon–carbon bond cleavage reactions. The substrates for these enzymes vary from species that are stable with respect to O2 under ambient conditions, to examples that in anionic form exhibit O2 reactivity in the absence of enzyme. Described herein are advances from studies of the enzymes themselves and model systems. These combined investigations provide insight into novel mechanistic pathways leading to aliphatic carbon–carbon bond cleavage and/or the factors that influence regioselectivity in the oxidative carbon–carbon bond cleavage reactions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Coordination Chemistry Reviews - Volume 257, Issues 21–22, November 2013, Pages 3005–3029
نویسندگان
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