کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1305675 1499174 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rational design of an arene ruthenium chlorin conjugate for in vivo anticancer activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Rational design of an arene ruthenium chlorin conjugate for in vivo anticancer activity
چکیده انگلیسی


• In vivo study of a dual photosensitizer and chemotherapeutic agent.
• Combination of arene ruthenium complex with chlorin for photodynamic therapy.
• Optimisations of the PDT treatment factors using a statistical model.

A tetranuclear p-cymene ruthenium 5,10,15,20-tetra(3-pyridyl)chlorin complex has been prepared and evaluated in vivo as dual photosensitizer and chemotherapeutic agent on mice bearing an ectopic human oral carcinoma xenograft. The in vivo study was planned using a statistical model. Optimisations of the treatment factors showed that the injected dose was critical, while the light–drug interval, fluence and fluence rate had only a modest impact. The ruthenium–chlorin conjugate was found to accumulate preferentially in the endoplasmic reticulum of KB cells. In addition, a mode of action in vivo dominated by a cytotoxic effect of the complex and not a photodynamic efficiency of the photosensitizer was suggested.

A tetranuclear p-cymene ruthenium 5,10,15,20-tetra(3-pyridyl)chlorin complex has been prepared and evaluated in vivo as dual photosensitizer and chemotherapeutic agent on mice bearing an ectopic human oral carcinoma xenograft. An in vitro study has showed that the ruthenium–chlorin complex accumulates preferentially in the endoplasmic reticulum. A mode of action in vivo dominated by a cytotoxic effect of the complex and not by photodynamic efficiency of the photosensitizer was suggested.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Inorganica Chimica Acta - Volume 414, 1 April 2014, Pages 134–140
نویسندگان
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