Novel ONN pincer type copper(II) hydrazide complexes: An investigation on the effect of electronegativity and ring size of heterocyclic hydrazides towards nucleic acid/protein binding, free radical scavenging and cytotoxicity

• Synthesis of new copper(II) pincer type hydrazide complexes.
• Binding interaction with both DNA and protein was estimated.
• In vitro free radical scavenging and cytotoxicity studies were also performed.

Four new, pincer type copper complexes 5–8 were synthesised from the reactions of CuCl2·2H2O with respective hydrazide ligands 1–4 (HL1–HL4) and characterized by various physicochemical techniques. The single crystal XRD and spectral data revealed that all the ligands are monoanionic, tridentate pincer analogues chelating agent, which coordinate via ONN donor atoms to the copper ion. The effect of electronegativity and ring size of heterocyclic hydrazide moiety of ONN pincer type copper(II) chelates on nucleic acid interaction and protein binding was investigated by in vitro experiments. In addition, scavenging activity and cytotoxicity of the newly synthesized complexes of the composition [Cu(L1–4)Cl] were also evaluated.

The synthesis and characterisation of pincer type bivalent copper hydrazide complexes of the composition [Cu(L1–4)Cl] have been presented.In vitro biological evaluations such as DNA/protein binding, radical scavenging and cytotoxicity were carried out.Figure optionsDownload as PowerPoint slide