کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1307804 | 975154 | 2006 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Chiral P-monodentate phosphoramidite and phosphite ligands for the enantioselective Pd-catalyzed allylic alkylation Chiral P-monodentate phosphoramidite and phosphite ligands for the enantioselective Pd-catalyzed allylic alkylation](/preview/png/1307804.png)
The improved synthesis of the chiral phosphoramidite Ia, based on a biphenol backbone and bearing chiral bis(1-phenylethyl)amine group on the phosphorus atom, is described together with its Pd(II) complex. The chiral complex cis-PdCl2L2 (L = Ia) has been characterized by X-ray crystal structure analysis and spectroscopic data. The series of the chiral P-monodentate phosphoramidite and phosphite ligands was tested in Pd-catalyzed enantioselective allylic substitution of different substrates. In the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate with dimethylmalonate, up to 79% ee was achieved with [Pd2(dba)3] × CHCl3 as precatalyst.
The improved synthesis of the chiral phosphoramidite Ia, based on a biphenol backbone and bearing chiral bis(1-phenylethyl)amine group on the phosphorus atom, is described together with its Pd(II) complex. The chiral complex cis-PdCl2L2 (L = Ia) has been characterized by X-ray crystal structure analysis and spectroscopic data. The series of the chiral P-monodentate phosphoramidite and phosphite ligands was tested in Pd-catalyzed enantioselective allylic substitution of different substrates. In the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylallyl acetate with dimethylmalonate, up to 79% ee was achieved.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 359, Issue 6, 10 April 2006, Pages 1826–1836