Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis

• Two triorganotin(IV) complexes with phenylcyanamide ligands were synthesized and characterized.
• The interaction of the triorganotin(IV) complexes with CT-DNA was investigated.
• The triorganotin(IV) complexes bind to bovine serum albumin proteins.
• The triorganotin(IV) complexes are cytotoxic and have antioxidant properties.

This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)2(μ-bp)(H2O)2], 1, and [(SnMe3)(4-NO2pcyd)], 2, (Me: methyl, bpH2: 4,4′-dicyanamidobiphenyl and 4-NO2pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (1H, 13C and 119Sn), Mössbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed.

The biological activity of triorganotin(IV) phenylcyanamide complexes prepared by sonochemical synthesis is reported.Figure optionsDownload as PowerPoint slide