New nanomedicine approaches using gold–thioguanine nanoconjugates as metallo-ligands

Gold–thioguanine nanoconjugates (AuNP–TG) of size 3–4 nm were synthesized and the ratio between gold and 6-thioguanine (TG) was estimated as ∼1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis. AuNP–TG constructs showed high in vitro stability under different pH conditions and biologically relevant solutions for a period of 24 h. Reaction of AuNP–TG with europium or platinum salts resulted in the formation of organized self-assembled metallo-networks.

Gold-thioguaninenanoconjugates (AuNP-TG) of average size 3.5 nm have been synthesized and characterized. The utility of AuNP-TG asmetallo-ligands has been established by complexing with Europium and Platinum salts. With europium, a novel hexagonal type metallo-network was formed and with platinum AuNP-TG forms a linear assembly.Figure optionsDownload as PowerPoint slideResearch highlights
► AuNP-TG conjugates of average size 3.5 nm have been synthesized.
► AuNP–TG conjugates are highly stable in biologically relevant conditions.
► AuNP–TG conjugates serve as metallo-ligands by complexing with Eu/Pt salts.
► With Europium, AuNP-TG forms a novel hexagonal metallo-network.
► With Platinum, AuNP-TG forms a linear self-assembly of nanoparticles.