[RuIII(medtra)(H2O)] (medtra = N-methylethylenediaminetriacetate) complex - A highly efficient NO inhibitor with low toxicity

Kinetic studies of the reaction between [Ru(medtra)(H2O)] and NO reveal that, despite being less labile than the corresponding hedtra3− and edta4− complexes, [Ru(medtra)(H2O)] exhibits the highest activity toward NO. In addition, NO scavenging studies with murine macrophages show that [Ru(medtra)(H2O)] is less toxic than the complex despite being least labile than the corresponding hedtra3− and edta4− complexes.