A reusable zigzag copper(II) coordination polymer with bio-essential constituents as a facile DNA scission agent

A copper(II) coordination polymer has been synthesized in the form of an infinite zigzag chain where each metal is bonded to one glycine, two adenine, one nitrate anion and a water molecule giving a distorted octahedral coordination geometry with N3O3 donor set. Each chain is hydrogen-bonded through C–H⋯O and N–H⋯O interactions on both sides leading to an overall polymeric structure. This compound not only shows facile chemical nuclease activity for pBR322 supercoiled DNA but also can be reused keeping its scission activity unchanged.

A copper(II) coordination polymer with ligation from adenine and glycine has been synthesized for cleavage of pBR322 supercoiled DNA through oxidative pathway and is reusable.Figure optionsDownload as PowerPoint slide