کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1310786 | 1499198 | 2012 | 13 صفحه PDF | دانلود رایگان |
This review gives an account of the coordination chemistry of thiosemicarbazone ligands with three (tridentate) or four (tetradentate) potential donor atoms. The syntheses and structures of the ligands complexes are described according to the donor atom combinations and metals involved. The review also covers the biological activities of the ligands and complexes in the context of their applications as therapeutic or diagnostic PET or SPECT imaging agents.
Thiosemicarbazones are potent cytotoxins and with appropriate radiometals can be used for diagnostic medical imaging or therapy.Figure optionsDownload as PowerPoint slideHighlights
► A review of the chemistry and biology of thiosemicarbazones.
► Their coordination chemistry with biologically relevant metals.
► Their applications in biomedicine for PET and SPECT imaging and therapy.
► Their mechanisms of actions in vitro and in vivo.
Journal: Inorganica Chimica Acta - Volume 389, 1 July 2012, Pages 3–15