کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1311583 | 975334 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2]](/preview/png/1311583.png)
The reaction of cis- and trans-[PtCl2(NCCH2Ph)2] with a 5-fold excess of MeNH2 and Me2NH in CH2Cl2 at −10 °C affords in high yield the bis-amidine derivatives cis- and trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] (1a, 2a) and cis- and trans-[PtCl2{E-N(H)C(NMe2)CH2Ph}2] (3a, 4a), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] (2a).Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines.
New benzylamidine complexes of the type cis- and trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2] and cis- and trans-[PtCl2{E-N(H)C(NMe2)CH2Ph}2] were obtained by reaction of the starting dinitrile complexes with an excess of MeNH2 and Me2NH, respectively. The characterization of the complexes was performed and their in vitro cytotoxicity was evaluated. The X-ray diffraction analysis was carried out for trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2].Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 361, Issue 11, 27 July 2008, Pages 3109–3116