کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1312853 | 975507 | 2006 | 10 صفحه PDF | دانلود رایگان |
Described herein is the synthesis of two platinum(II) complexes containing l-ornithine (1) or d-ornithine (2) as a ligand. The complexes were obtained by the direct reaction of aqueous solutions of potassium tetrachloroplatinate and l- or d-ornithine. The single crystal structures of 1 and 2 were determined and indicated that the Pt core is surrounded by an almost regular square planar coordination environment. The two complexes were thoroughly characterized by means of FT-IR, FT-Raman and NMR techniques. Furthermore, their ability to inhibit proliferation of human tumor cell lines was tested and the results indicate that 1 and 2 exert different cytotoxic effects. Particularly, the complex with the d-isomer of ornithine (2) showed a significantly greater cytotoxicity than that with the l-isomer (1). Finally, circular dichroism analysis indicated that 1 and 2 interact with DNA in a manner similar to that of cisplatin.
The synthesis and spectroscopic characterization of platinum(II) complexes with l- and d-ornithine ligands are described and the single crystal structure was determined. The biological studies evidence the ability to inhibit cell growth and to interact with DNA.Figure optionsDownload as PowerPoint slide
Journal: Inorganica Chimica Acta - Volume 359, Issue 13, 1 October 2006, Pages 4197–4206