کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1316016 | 976416 | 2011 | 10 صفحه PDF | دانلود رایگان |

The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)2(L)](ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distorted trigonal–bipyramidal geometry for all the molecules. The complex formation constants were determined in nonaqueous media by spectrophotometric measurements. Testing copper(II) complexes in mouse neuroblastoma N2a cells persistently infected with the 22L strain of the scrapie prion protein (22L-N2a) resulted in high cytotoxicity but no antiprion activity at nontoxic doses.
The synthesis, structures and complex formation constants of C1 = [Cu(phen)2(2-imidazolidinethione)](ClO4)2, C2 = [Cu(phen)2(1-methyl-2-imidazolidinethione)](ClO4)2, C3 = [Cu(phen)2(1,3-dimethyl-2-imidazolidinethione)](ClO4)2, C4 = [Cu(phen)2(1-ethyl-2-imidazolidinethione)](ClO4)2 and C5 = [Cu(phen)2(1,3-diethyl-2-imidazolidinethione)](ClO4)2 complexes have been studied. Testing complexes in mouse neuroblastoma infected with strain of scrapie prion protein (22L–N2a) resulted in high cytotoxicity. Correlation between cytotoxicity and formation constants has been evaluated. phen=1,10-ortho-phenantroline, C0 = Cu(phen)2(ClO4)2.Figure optionsDownload as PowerPoint slide
Journal: Journal of Inorganic Biochemistry - Volume 105, Issue 3, March 2011, Pages 329–338