Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands

The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives – the so-called Joseph ligands – are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity.

Graphical AbstractA panel of seven cisplatin-like complexes containing bis(imidazole) derivatives were designed and synthesized. Their physico-chemical properties and in vitro biological activity were experimentally evaluated and studied in silico.Figure optionsDownload as PowerPoint slide