کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1317142 976509 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxicity, qualitative structure–activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Cytotoxicity, qualitative structure–activity relationship (QSAR), and anti-tumor activity of bismuth dithiocarbamate complexes
چکیده انگلیسی

Bismuth dithiocarbamate complexes of general formula Bi(S2CNR2)3 demonstrate potent in vitro cytotoxicity against a panel of seven human cancer cell lines; a structure–activity relationship has been established. Potency exhibited by the R = Et (2) derivative, for example, is unrivalled by standard cancer drugs with the exception of paclitaxel. In vivo studies indicate a significant anti-tumor effect exerted by (2) against both OVCAR-3, an ovarian cancer cell line, and HT-29, a colon carcinoma cell line.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 101, Issue 5, May 2007, Pages 809–816
نویسندگان
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